Membrane filters retain matter primarily due to size differences between the molecules and the pores in the membrane. The precise nature of porous synthetic membranes used in the CFF product range makes them ideal for bioprocess purification and recovery. The key advantage of a positive barrier is that it allows optimal performance under broad variation in feed stream conditions.
Membrane Solutions' manufacturing technology provides sharp cut-off to enhance clarification and fractionation applications. Our filters are engineered specifically for accurate linear scale-up, and our family of CFF and NFF devices offers consistent performance, excellent durability, and ease of use.
How cross-flow membranes work
The feed stream moves parallel to the membrane surface (Cross Flow) and purified liquid or unwanted contaminants pass through the membrane (Permeate). Most of the particulates and aggregates are carried along by the cross flow. Flow and pressure will often reach steady state allowing high throughput processing.
How normal flow filters work
The feed stream moves perpendicular to the membrane and purified liquid passes through the membrane (Filtrate). Particulates and aggregates are retained in the pores or form a "filter cake", reducing flow and/or increasing pressure over time.